I'd hazard a guess that this game (Untitled) by jodi is pretty much impossible to play. Sounds like Doom or Wolfenstein in which all the pixels and the 3D environment mapping has been messed up. Intriguing.
Edit: it's a hacked version of Quake and can be downloaded here.
In a similar vein, Cory Arcangel somehow transformed his computer data into some fancy looking glitch art! Pretty awesome. Found via turbulence.org.